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Insegnamento
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CFU
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SSD
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Ore Lezione
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Ore Eserc.
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Ore Lab
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Ore Studio
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Attività
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Lingua
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8065588 -
ANALITYCAL CHEMISTRY (LAB)
(obiettivi)
Aim: principles of analysis of the molecules with the principal system of identification.----------------------------------------------------Quantitative and qualitative analaysis; Error; Data
analysis; Equilibrium in solution; Titrations
Voltammetry and polarography; Systematic
analysis; Elements of atomic spectroscopy; Elements of Molecular spectroscopy; Polarimetry.
Suggested
texbooks
Fundamentals of analytical chemistry. Crouch,
Skoog, West, Holler. 8th edition 2003, (or more recent), Brooks/Cole ISBN-10:
0534417973
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8
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CHIM/03
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24
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120
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Attività formative di base
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ENG |
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8066718 -
MICROBIOLOGY AND IMMUNOLOGY
(obiettivi)
Aim:The course provides the essential knowledge of
the major concepts, principles and applications of microbiology. Trough this
course you will learn about what microorganisms are, how they function, and how
their related pathogenetic mechanism work. Areas covered are: Microbiology;
Bacteriology; Mycology; Parassitology; Virology. These objectives will be
achieved through lectures, seminars and educational interactive activities
designed to facilitate learning, and to improve the ability to address and
resolve the main questions of Medical Microbiology. Some peculiar arguments and
topics will be presented and studied in depth.------------------------------------------General Bacteriology
Criteria for classification and taxonomy of bacteria. The
bacterial cell. Bacterial spores. Bacterial genetics. Metabolism and bacterial
growth. Host-parasite relationship: the action of pathogenic bacteria. Immune
sera and vaccines. Principles of microbiological diagnostics. Antibacterial
drugs and mechanisms of resistance.
Special Bacteriology
Staphylococci. Streptococci. Pneumococci.
Enterococci. Bacilli and clostridia. Corinebatteri and Listeria.
Enterobacteriaceae. Pseudomonas. Vibrios. Campylobacter and Helicobacter. Haemophilus. Bordetella and
Brucella. Yersinia and Pasteurella. Neisseria. Anaerobic microorganisms. Legionella. Mycobacteria. Spirochete.
Mycoplasma. Rickettsiae. Chlamydia.
General Mycology
The mycetes: structure, dimorphism and replication. Mechanisms of pathogenicity.
Special Mycology
Mycosis by opportunistic fungi. Mycosis superficial, skin,
subcutaneous and systemic.
General Parasitology
Systematics and zoological nomenclature. Biological associations.
General information about life cycles of pests. Parasitic specificity.
Parasite-host interactions. Pathogenic action of parasites. Parasitic diseases
of medical importance.
Special Parasitology
Protozoan parasites of man. Cestodes, trematodes and nematodes of
human relevance.
Arthropod pests and vectors of major human parasitic diseases.
General Virology
Nature, origin and morphology of viruses. Viral nucleic acids,
proteins and lipids. Multiplication of animal viruses. Virus-cell interaction.
Persistence and latency. Cell culture, cycle reproductive isolation of animal
viruses, adaptation and virulence. Inactivation of viruses: physical and
chemical agents. Cell surface antigens encoded by viruses. Immune response to
viral infection. Interferons. Vaccines. Antiviral chemotherapy.
Special Virology
Adenovirus. Herpesvirus. Poxvirus. Papovavirus. Parvovirus.
Picornavirus. Mixovirus. Paramyxovirus. Rhabdovirus. Togavirus and other
viruses transmitted by insects. Filoviruses. Rubella virus. Reovirus and
rotavirus. Hepatitis. Retrovirus. Human Retroviruses. Oncogenic RNA and DNA
viruses. Prions.
ImmunologyInnate (Non-Specific) and Acquired (Specific ) Immunity; Cell and
organs of the Immune System Hematopoiesis; Enrichment of hematopoietic stem
cells; Clinical uses of pluripotent stem cells; B-lymphocytes: maturation,
activation and differentiation; Major Hystocompatibility Complex; Antigens; Antigen
processing and presentation; Immunoglobulins: structure and function; Polyclonal
antibodies and monoclonal antibodies Antigen-antibody interactions; T-lymphocytes:
maturation, activation and differentiation; T-cell receptors; Cytokines; The
Complement System; Leukocyte migration and inflammation; Cell-mediated and
humoral effector responses; Cytotoxicity; Hypersensitive reactions; Vaccines; Autoimmunity;
Immunodeficiency diseases; The Immune System in AIDS; Transplantation
immunology: basis and manifestations of graft rejection, tissue
Typing, immunosuppressive therapy; Cancer and Immune System; Experimental
Systems in Immunology: animal models, cell culture systems.
Suggested textbooks
Immunobiology from P. Travers,
C.A. Janeway.
Cellular and Molecular
Immunology from A.K. Abbas, A.H. Lichtman.
Patrick R. Murray, Ken S. Rosenthal, Michael A. Pfaller “Medical
Microbiology”,
6th Edition, 2008.
Slide set of the
lessons.
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6
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MED/07
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48
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Attività formative di base
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ENG |
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8066634 -
MOLECULAR BIOLOGY
(obiettivi)
Aim:The
object of the course is to create general understanding amongst the students in
the subject of molecular biology. The students will have basic knowledge of the
molecular biology both in prokaryotic and eukaryotic systems. The students will
learn about classics molecular biology methodologies as well as new techniques to
understand the new findings of the genomic approach. It is expected that they
will be more confident to use the acquired knowledge in pursuing their future
orientation as pharmacists or in drug development and other industrial
applications.----------------------------------------Nucleotides: structure and properties; The double helix;
Semiconservative replication; Chemistry of DNA; Supercoiling; Chromatin
components and structure; Histone-DNA interactions; Histone posttranslational modifications;
Gene expression and methylation; Sequence components; Repetitive and non repetitive
DNA; Genes: shapes, sizes and structures; Polycistronic bacterial genes;
Eukaryiotic genes are interrupted; Gene families; Bacterial genome is a single
replicon while eukaryotic chromosomes contains many; Origin of replication; DNA
polymerases; Proteins participating to DNA replication; The two DNA strands are
replicated in a coordinated manner; Systems that repair DNA; Messenger RNA:
structure and function; Eukaryotic mRNAs structure; Eukaryotic mRNAs splicing
and processing; Transfer RNA: structure and function; tRNA primary, secondary
and tertiary structure; Ribosomal RNA: structure and function; Bacterial RNA
polymerases; Sigma factors and the control of bacterial transcription; Transcription
units; Bacterial transcription: initiation, synthesis and termination; Eukaryotic
RNA polymerases; RNA polymerase II promoters; Transcription factors cooperating
with RNApol II in transcription initiation; The process of mRNA transcription
initiation; Transcription factors: DNA sequences recognition, structures and
function; General mechanisms for activation or repression of transcription;
Homeo domains; Leucine zippers; Steroid hormone receptors; Chromatin structure
and transcription; Histone methylation and acetylation regulate transcription; Protein
expression can be regulated various step other than transcription; Genetic code;
tRNA and mRNA roles; Ribosomes: structure and function; tRNA activation;
Codon-anticodon recognition; Initiation, elongation and termination of protein
synthesis; Restriction enzymes; Plasmids; DNA sequences can be obtained in
various ways; Vectors for cloning DNA; DNA cloning; RNA can be copied in DNA;
Gene isolation from genomes; Chromosome walking; The human genome project; Nucleic
acids hybridising; Methods for studying mRNA expression; Polymerase chain
reaction; DNA sequencing; Cloned genes can be expressed in prokaryotic and
eukaryotic systems.
Suggested textbooks
Genes VIII , Lewin.
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M-4190 -
MOLECULAR BIOLOGY MOD I
(obiettivi)
Aim:The object of the course is to create general understanding amongst the students in the subject of molecular biology. The students will have basic knowledge of the molecular biology both in prokaryotic and eukaryotic systems. The students will learn about classics molecular biology methodologies as well as new techniques to understand the new findings of the genomic approach. It is expected that they will be more confident to use the acquired knowledge in pursuing their future orientation as pharmacists or in drug development and other industrial applications.----------------------------------------Nucleotides: structure and properties; The double helix;
Semiconservative replication; Chemistry of DNA; Supercoiling; Chromatin
components and structure; Histone-DNA interactions; Histone posttranslational modifications;
Gene expression and methylation; Sequence components; Repetitive and non repetitive
DNA; Genes: shapes, sizes and structures; Polycistronic bacterial genes;
Eukaryiotic genes are interrupted; Gene families; Bacterial genome is a single
replicon while eukaryotic chromosomes contains many; Origin of replication; DNA
polymerases; Proteins participating to DNA replication; The two DNA strands are
replicated in a coordinated manner; Systems that repair DNA; Messenger RNA:
structure and function; Eukaryotic mRNAs structure; Eukaryotic mRNAs splicing
and processing; Transfer RNA: structure and function; tRNA primary, secondary
and tertiary structure; Ribosomal RNA: structure and function; Bacterial RNA
polymerases; Sigma factors and the control of bacterial transcription; Transcription
units; Bacterial transcription: initiation, synthesis and termination; Eukaryotic
RNA polymerases; RNA polymerase II promoters; Transcription factors cooperating
with RNApol II in transcription initiation; The process of mRNA transcription
initiation;
Suggested textbooks
Genes VIII , Lewin.
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5
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BIO/11
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40
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-
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-
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-
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Attività formative caratterizzanti
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ENG |
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M-4189 -
MOLECULAR BIOLOGY MOD II
(obiettivi)
Aim:The object of the course is to create general understanding amongst the students in the subject of molecular biology. The students will have basic knowledge of the molecular biology both in prokaryotic and eukaryotic systems. The students will learn about classics molecular biology methodologies as well as new techniques to understand the new findings of the genomic approach. It is expected that they will be more confident to use the acquired knowledge in pursuing their future orientation as pharmacists or in drug development and other industrial applications.----------------------------------------Transcription factors: DNA sequences recognition, structures and
function; General mechanisms for activation or repression of transcription;
Homeo domains; Leucine zippers; Steroid hormone receptors; Chromatin structure
and transcription; Histone methylation and acetylation regulate transcription; Protein
expression can be regulated various step other than transcription; Genetic code;
tRNA and mRNA roles; Ribosomes: structure and function; tRNA activation;
Codon-anticodon recognition; Initiation, elongation and termination of protein
synthesis; Restriction enzymes; Plasmids; DNA sequences can be obtained in
various ways; Vectors for cloning DNA; DNA cloning; RNA can be copied in DNA;
Gene isolation from genomes; Chromosome walking; The human genome project; Nucleic
acids hybridising; Methods for studying mRNA expression; Polymerase chain
reaction; DNA sequencing; Cloned genes can be expressed in prokaryotic and
eukaryotic systems.
Suggested textbooks
Genes VIII , Lewin.
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5
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BIO/11
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40
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-
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-
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-
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Attività formative caratterizzanti
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ENG |
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8065592 -
DRUGS ANALYSIS
(obiettivi)
The aim of the course is to give knowledges on therapeutic drug
monitoring as well as onanalysis of specific drugs of abuse in the clinical biochemistry
laboratory.------------Program introduces students to Pharmacogenetics with the
goal of preparing them to a likely future prospect: individualize drug prescribing
on the basis of an individual genotype; Clinical utility and indications, blood
sample collection and processing; Serum drug concentrations and their
significance; Therapeutic range, elimination half-life, recommendation for
blood sampling, elimination, clinical aspects; Immunosuppressive drugs
(cyclosporine, tacrolimus), antiepileptic drugs (carbamazepine, phenytoin,
phenobarbital, valproic acid), antibiotics (vancomicin, amikacyn),
antineoplastic drugs (metotrexate), lithium, theophylline, digoxin; Alcohol,
cocaine, opiates, barbiturates, cannabinoids, amphetamines; General concepts,
screening methods and confirmation tests;The need for predictive
pharmacogenetics-based therapeutic recommendations; Applications in oncology,
gastroenterology, rheumatology, psychiatry, acute and chronic pain,
cardiovascular diseases; Assay techniques: restriction length polymorphisms,
sequencing, microarray; Cytochromes P450 family, glutathione s-transferases,
N-acetyltransferase, thiopurine s-methyltrasnferase,
UDP-glucuronosuyltransferases, diidropirimidina deidrogenasi, oppioid receptor,
catecol-O-methyltransferase, P-glycoprotein.
Fundamental theoretical principles; Physical
and chemical properties of drug molecules; Systematic qualitative inorganic
analysis; Flame spectrometry, Common apparatus and basic techniques; Separative
techniques; Spectroscopic techniques; Pharmaceutical analysis of some Inorganic
drugs.
Suggested textbooks
David G. Watson, Pharmaceutical Analysis, Elsevier 2005.
Lecture Notes +
Journal articles provided by the teacher
A Textbook for Pharmacy Students and Pharmaceutical Chemists. David G. Watson, Elsiever 2005
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M-1217 -
METHODOLOGY
(obiettivi)
The aim of the course is to give knowledges on therapeutic drug monitoring as well as onanalysis of specific drugs of abuse in the clinical biochemistry laboratory.------------Fundamental theoretical principles; Physical
and chemical properties of drug molecules; Systematic qualitative inorganic
analysis; Flame spectrometry, Common apparatus and basic techniques; Separative
techniques; Spectroscopic techniques; Pharmaceutical analysis of some Inorganic
drugs.
Suggested
texbooks
A Textbook for Pharmacy Students and
Pharmaceutical Chemists. David G. Watson, Elsiever 2005
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5
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CHIM/08
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40
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-
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-
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-
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Attività formative caratterizzanti
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ENG |
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M-1218 -
APPLICATIONS
(obiettivi)
The aim of the course is to give knowledges on therapeutic drug monitoring as well as onanalysis of specific drugs of abuse in the clinical biochemistry laboratory.------------The Program introduces students to Pharmacogenetics with the
goal of preparing them to a likely future prospect: individualize drug prescribing
on the basis of an individual genotype; Clinical utility and indications, blood
sample collection and processing; Serum drug concentrations and their
significance; Therapeutic range, elimination half-life, recommendation for
blood sampling, elimination, clinical aspects; Immunosuppressive drugs
(cyclosporine, tacrolimus), antiepileptic drugs (carbamazepine, phenytoin,
phenobarbital, valproic acid), antibiotics (vancomicin, amikacyn),
antineoplastic drugs (metotrexate), lithium, theophylline, digoxin; Alcohol,
cocaine, opiates, barbiturates, cannabinoids, amphetamines; General concepts,
screening methods and confirmation tests;The need for predictive
pharmacogenetics-based therapeutic recommendations; Applications in oncology,
gastroenterology, rheumatology, psychiatry, acute and chronic pain,
cardiovascular diseases; Assay techniques: restriction length polymorphisms,
sequencing, microarray; Cytochromes P450 family, glutathione s-transferases,
N-acetyltransferase, thiopurine s-methyltrasnferase,
UDP-glucuronosuyltransferases, diidropirimidina deidrogenasi, oppioid receptor,
catecol-O-methyltransferase, P-glycoprotein.
Suggested textbooks
David G. Watson, Pharmaceutical Analysis, Elsevier 2005.
Lecture Notes +
Journal articles provided by the teacher
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5
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CHIM/08
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-
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120
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Attività formative caratterizzanti
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ENG |
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8066719 -
PHARMACEUTICAL BIOLOGY AND PHARMACOLOGY
(obiettivi)
The module aims at studying
the main targets of drug action with special emphasis to biodrugs, innovative
pharmacological therapies and recent research on novel targets and its application
in the design of therapeutics.--------------
General principles of biological drug targets.
Biological drug targets:
Components of cell membrane; Secreted proteins; Signal
transduction pathways; Mitochondria; RNA (oligonucleotide
anti-sense, RNA interference); DNA, telomere structures and telomerase; DNA repair
enzymes; Cell cycle checkpoints; Epigenetic-enzymes; Proteasome pathway.
Suggested textbooks
Goodman & Gilman’s The Pharmacological Basis of Therapeutics,
11th Edition (2005),
Laurence Brunton, John Lazo, Keith L Parker, McGraw Hill.
The Cell: A Molecular Approach, 5th ed. (2009), G.M. Cooper and
R.E. Hausman, ASM
Press and Sinauerc Associates, Inc.
Lecture notes from the lessons.
Hammond: Cellular and Molecular
Neurophysiol
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7
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BIO/14
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56
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Attività formative caratterizzanti
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ENG |
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8063953 -
STATISTICS
(obiettivi)
Aim: principles of Medical Statistics.___________________________Defining the objectives; Methods of
randomisation; Laboratory experiments; Experimental units; Types of studies;
Randomised studies; Cohort studies; Case-control studies; Cross-sectional studies;
Types of data; Frequency distributions; Histograms and other frequency graphs;
Shapes; Of frequency distributions; Cumulative distributions; Median and
quantiles; The means (arithmetic, geometric…); Variance and standard deviation;
Degrees of freedom; Rates and proportions; Significant figures; Presenting
tables; Pie chart; Bar charts; Scatter diagrams; Misleading graphs; Probability;
Properties of probabilities; Conditional probabilities; Bayes formula; Probability
distributions and random variables; The binomial distribution; The Poisson
distribution; Probability for continuous variables; The normal distribution;
Properties of the normal Distribution; The normal plot; P-P plot; Standardised
normal table; Sampling and sampling distributions; Standard error of a sample
mean; Standard error; Of a proportion; Confidence intervals; The difference
between two means; The difference between two proportions; Testing a hypothesis;
Principles of significance tests; The null hypothesis; Significance; Levels and
types of errors; The p-value; One and two sided tests; Comparing the means of
large samples; Comparing two proportions; Comparing the means of small samples (the
t-distribution); Comparing two variances (the F-distribution); Scatter diagrams;
Regression; Using the regression line for prediction; Analysis of Residuals; Significance test for the
regression coefficient; Correlation; Significance test for the correlation
coefficient; The Mann Whitney U test; The Wilcoxon matched pairs test;
Spearman’s rankCorrelation coefficient; Kendall’s rank correlation coefficient;
Parametric or non Parametric methods; The chi-squared test for association;
Tests for 2 by 2 tables; Yates continuity correction for the 2 by 2 table; The
odds ratio; Standard error for the log odds ratio.
Suggested textbooks
An Introduction to Medical Statistics, M.
Bland, Oxford
Medical Publications, 2008.
Medical Statistics: a commonsense approach,
M.J. Campbell and M. Machin, Wiley, NY,
1999.
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5
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MED/01
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36
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24
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Attività formative di base
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ENG |
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8066702 -
BIOCHEMISTRY
(obiettivi)
The Biochemistry aims to provide students with a thorough understanding of the structure-function relationships of the main classes of biomolecules, and to provide the basis for the study of metabolism and its regulation.----------------------------------Biomolecules and Biochemical Methods; Water and pH;Aminoacids and
Peptides; Proteins: Structure and Function; Myoglobin and Hemoglobin; Enzymes:
Properties, Kinetics, Mechanism of Action, Regulation of Activity, Inhibitors; Water
Soluble Vitamins and Coenzymes; Bioenergetics: The Role of ATP, Biological Oxidation, The Respiratory Chain
andOxidative Phosphorylation; Carbohydrates of Physiologic
Significance; Lipids of Physiologic Significance; Lipid Soluble Vitamins; Purines,
Pyrimidines and Nucleic Acids; Nutrition, Digestion and Absorption of Proteins,
Lipids and Carbohydrates; Overview of Intermediary Metabolism; Glycolysis and
the Oxidation of Pyruvate; Metabolism of Glycogen, Gluconeogenesis and
Control of the Blood Glucose; The Pentose Phosphate Pathway and other Pathway
of Hexose Metabolism; The Citric Acid Cycle;Fatty Acids Oxidation: Ketogenesis.
Metabolism of Unsaturated Fatty Acids and Eicosanoids; Biosynthesis of Fatty Acids.
Cholesterol Synthesis, Transport and Excretion; Integration of Metabolism and
the Provision of Tissue Fuels; Lipid Transport and Storage; Catabolism of Proteins
and of Aminoacid Nitrogen; Transamination; Oxidative Deamination; Urea
cycle; Nucleotides, Metabolism of Purine
and Pyrimidine Nucleotides.
Suggested textbooks
Harper’s Illustrated Biochemistry 28th ed.
R.K. Murray, D.A. Bender, K.M. Botham, P.J. Kennelly, V.W.
Rodwell, P.A. Weil.
Principles of Biochemistry, Biochemistry 6th edition by Berg and
Stryer/Lehninger
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M-4340 -
BIOCHEMISTRY MOD. 2
(obiettivi)
The
Biochemistry aims to provide students with a thorough understanding
of the structure-function relationships of the main classes of biomolecules, and to provide the basis for the study of
metabolism and its regulation.----------------------------------The Pentose Phosphate Pathway and other Pathway
of Hexose Metabolism; The Citric Acid Cycle;Fatty Acids Oxidation: Ketogenesis.
Metabolism of Unsaturated Fatty Acids and Eicosanoids; Biosynthesis of Fatty Acids.
Cholesterol Synthesis, Transport and Excretion; Integration of Metabolism and
the Provision of Tissue Fuels; Lipid Transport and Storage; Catabolism of Proteins
and of Aminoacid Nitrogen; Transamination; Oxidative Deamination; Urea
cycle; Nucleotides, Metabolism of Purine
and Pyrimidine Nucleotides.
Suggested textbooks
Harper’s Illustrated Biochemistry 28th ed.
R.K. Murray, D.A. Bender, K.M. Botham, P.J. Kennelly, V.W.
Rodwell, P.A. Weil.
Principles of Biochemistry, Biochemistry 6th edition by Berg and
Stryer/Lehninger
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5
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BIO/10
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40
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-
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-
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-
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Attività formative caratterizzanti
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ENG |
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M-4339 -
BIOCHEMISTRY MOD. 1
(obiettivi)
The Biochemistry aims to provide students with a thorough understanding of the structure-function relationships of the main classes of biomolecules, and to provide the basis for the study of metabolism and its regulation.----------------------------------Biomolecules and Biochemical Methods; Water and pH;Aminoacids and
Peptides; Proteins: Structure and Function; Myoglobin and Hemoglobin; Enzymes:
Properties, Kinetics, Mechanism of Action, Regulation of Activity, Inhibitors; Water
Soluble Vitamins and Coenzymes; Bioenergetics: The Role of ATP, Biological Oxidation, The Respiratory Chain
andOxidative Phosphorylation; Carbohydrates of Physiologic
Significance; Lipids of Physiologic Significance; Lipid Soluble Vitamins; Purines,
Pyrimidines and Nucleic Acids; Nutrition, Digestion and Absorption of Proteins,
Lipids and Carbohydrates; Overview of Intermediary Metabolism; Glycolysis and
the Oxidation of Pyruvate; Metabolism of Glycogen, Gluconeogenesis and
Control of the Blood Glucose.
Suggested textbooks
Harper’s Illustrated Biochemistry 28th ed.
R.K. Murray, D.A. Bender, K.M. Botham, P.J. Kennelly, V.W.
Rodwell, P.A. Weil.
Principles of Biochemistry, Biochemistry 6th edition by Berg and
Stryer/Lehninger
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6
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BIO/10
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48
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-
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-
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Attività formative caratterizzanti
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ENG |
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8066402 -
CHEMISTRY OF EQUILIBRIA
(obiettivi)
Aim: the chemical basis of the solution, foundamental principles of thermodynamics and electrochemical properties.--------------------------------Chemical equilibria; The reaction kinetics and the
catalysis; The basic thermodynamics of the chemical equilibria; The heat, the
enthalpy, the entropy and the Gibbs free energy; The
redox reactions and the basis of electrochemistry; The solutions; The electrolytes; The ionic dissociation and the weak dissociation equilibria; The
hydrolysis of salts; The buffers; The pH scale; Basic
electrochemistry, the conducibility and potentiometry; The
Nernst equation and the electrochemical scale of redox potentials; The
coordination chemistry in solution and its use for chemical analysis and
microanalysis;
Suggested textbooks
Chemistry , Science of Change (3rd ed.
1998, 4th ed. 2003), D.W. Oxtoby, W.H.
Freeman, and T. Black, Harcourt-Brace.
Chemistry: The Molecular Nature of Matter
and Change (4th ed.), M. Silverberg,
McGraw-Hill, 2006.
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6
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CHIM/01
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24
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72
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Attività formative di base
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ENG |
