Università degli Studi di Roma "Tor Vergata"

Aim: Study of the principal basis of the molecular pharmacology applied to human system and notion of pharmacogenomics.--------------------------------Pharmacodynamics: relationship dose/effects; series of doses; ED50, LD50, Therapeutic window; Receptors: Classification, Structural, Functional Organization And Pharmacological Modulation; Ionotropic Receptors And Metabotropic Receptors; Methods For The Study Of Membrane Receptors;Protein Kinases And Their Role In Signal Transduction; Regulation Of Intracellular Calcium Homeostasis; Voltage-Deprendent Ion Channels; Neurotransporters: Molecular Structure, Activation Mechanisms And Pharmacological Modulation Of Neurotransporters; Neurotransmitters: Cholinergic Transmission, Catecholaminergic Transmission, Serotonergic Transmission, Gabaergic Transmission, Excitatory Amino Acid Transmission, Nitric Oxide, Opioid System, Cannabinoids; Tolerance, Drug Dependence, Prescription Medicines And Otc Medicines; Clinical Trials (placebo, randomization, blind design, ethics); Homeopathic School; Introduction To Toxicology; Toxicokinetics, Mechanisms Of Toxicity, Cellular Toxicity, Genetic Toxicology, Carcinogenesis, Mechanisms And Pathogenesis Of Developmental Toxicity; Basis Of Adverse Drug Reaction: Drug Allergy, Drug Idiosyncrasy; Target Organ Toxicity Induced By Drugs.Scope and aims of pharmacokinetics; Utility of pharmacokinetics in pharmacotherapy and drug development; Pharmacokinetic parameters (Ke, Clearance, Vd, t1/2); Steady-state; Relationship between persistence in the body and effect; Passage through biological membranes; Cell barriers; Absorption, Biological dosage (bioassay), Bioavailability, Pre-systemic elimination; Binding to plasma proteins and Pharmaco-toxicological consequences of plasma protein binding displacement, Drug interactions; Accumulation and storage tissues; Renal and biliary excretion; Dose-concentration relationship, saturation kinetics; Kinetic variability: influence of genetic factors, interactions, pathologies; Metabolism of drugs; Enzymatic induction: mechanisms and kinetics, pharmacological and toxicological consequences; Enzymatic inhibition: mechanisms and kinetics, pharmacological and toxicological consequences, main inhibitors of CYP450; Genetic polymorphism of metabolizing enzymes.Definitions of
Key Terms and Basic PGx Principles; Applications of PGx in Drug Discovery; Applications
of PGx in Clinical Trials; PGx Applications in Drug Metabolism; From Genotyping
to Drug Label-Challenges; The Genetics of Adverse Drug Reactions; Translation
of Genomic Biomarkers and their clinical utility; PGx and Cardiovascular Drugs;
PGx Applications in Children; PGx of Rare and Monogenic Disorders; PGx: The
Regulatory Environment and Labeling Implications.



Suggested textbooks

Goodman and
Gilman: The pharmacological basis of therapeutics, XI ed. McGraw-Hill; Clementi F., Fumagalli G.:
Farmacologia generale e molecolare, III ed. UTET.

Hammond, Cellular and Molecular Neurophysiology, III ed. Academic Press;
Casarett & Doull’s Toxicology: The Basic Science of Poisons, VII ed.
McGraw-Hill.