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Docente
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BERNARDINI SERGIO
(programma)
The Program introduces students to Pharmacogenetics with the goal of preparing them to a likely future prospect: individualize drug prescribing on the basis
of an individual genotype; Clinical utility and indications, blood sample collection and processing; Serum drug concentrations and their significance;
Therapeutic range, elimination half-life, recommendation for blood sampling, elimination, clinical aspects; Immunosuppressive drugs (cyclosporine,
tacrolimus), antiepileptic drugs (carbamazepine, phenytoin, phenobarbital, valproic acid), antibiotics (vancomicin, amikacyn), antineoplastic drugs
(metotrexate), lithium, theophylline, digoxin; Alcohol, cocaine, opiates, barbiturates, cannabinoids, amphetamines; General concepts, screening methods and
confirmation tests;The need for predictive pharmacogenetics-based therapeutic recommendations; Applications in oncology, gastroenterology,
rheumatology, psychiatry, acute and chronic pain, cardiovascular diseases; Assay techniques: restriction length polymorphisms, sequencing, microarray;
Cytochromes P450 family, glutathione s-transferases, N-acetyltransferase, thiopurine s-methyltrasnferase, UDP-glucuronosuyltransferases, diidropirimidina
deidrogenasi, oppioid receptor, catecol-O-methyltransferase, P-glycoprotein.
 Suggested textbooks
David G. Watson, Pharmaceutical Analysis, Elsevier 2005.
Lecture Notes + Journal articles provided by the teacher
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