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Docente
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MACCHI BEATRICE
(programma)
General principles of biological drug targets.
Biological drug targets:
Components of cell membrane; Secreted proteins; Signal transduction pathways; Mitochondria; RNA (oligonucleotide anti-sense, RNA interference); DNA,
telomere structures and telomerase; DNA repair enzymes; Cell cycle checkpoints; Epigenetic-enzymes; Proteasome pathway.
 Suggested textbooks
Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 11th Edition (2005),
Laurence Brunton, John Lazo, Keith L Parker, McGraw Hill.
The Cell: A Molecular Approach, 5th ed. (2009), G.M. Cooper and R.E. Hausman, ASM
Press and Sinauerc Associates, Inc.
Lecture notes from the lessons.
Hammond: Cellular and Molecular Neurophysiol
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